Nvidia miners work really well for mining Equihash based cryptocurrencies, like Zcash and ZenCash.
I have not had a chance to set up an Nvidia card miner yet, but if I do I will use either the latest version of Ethosdistro, which supports Nvidia cards now, or Ubuntu.
The ZenCash community is great, especially for mining. I was talking with one of the guys on there, @masterdubs, who shared a how-to for mining ZenCash with Nvidia.
His first post is How to set up a ZenCash wallet for Mac, which is helpful to get an address to mine to.
And his next post is How to Mine ZenCash on Ubuntu 16.04 with Nvidia GTX 1070.